Photosynthesis & Respiration

Stage-by-stage breakdown — A-Level Biology

6CO₂ + 6H₂O → C₆H₁₂O₆ + 6O₂   (light energy required)
1
Light-Dependent Reactions
Thylakoid membranes

Light energy is absorbed by chlorophyll in photosystems II and I (PSii first, then PSi). This energy excites electrons, which pass along the electron transport chain embedded in the thylakoid membrane.

Water is photolysed (split by light): 2H₂O → 4H⁺ + 4e⁻ + O₂. The H⁺ ions accumulate in the thylakoid space, creating a proton gradient. They flow back through ATP synthase (chemiosmosis), generating ATP.

NADP⁺ is reduced to NADPH at the end of PSi, using the electrons and H⁺ ions. Both ATP and NADPH move to the stroma for the next stage.

InputsLight energy, H₂O, ADP + Pi, NADP⁺
OutputsATP, NADPH (reduced NADP), O₂
Exam tip: PSii comes before PSi in the pathway — the numbering reflects discovery order, not sequence. A common trick question.
2
Calvin Cycle (Light-Independent)
Stroma

Carbon fixation: CO₂ combines with ribulose bisphosphate (RuBP, a 5C compound) using the enzyme RuBisCO, forming two molecules of glycerate-3-phosphate (GP, 3C).

Reduction: GP is reduced to glyceraldehyde-3-phosphate (GALP/G3P, 3C) using ATP and NADPH from the light-dependent reactions.

Regeneration: Most G3P is used to regenerate RuBP (using ATP). One in six G3P molecules leaves the cycle to form glucose (two G3P → one glucose).

InputsCO₂, ATP, NADPH, RuBP
OutputsG3P (→ glucose), ADP + Pi, NADP⁺ (recycled)
Exam tip: 6 turns of the Calvin cycle are needed to make 1 glucose (6 CO₂ fixed). Also know that RuBisCO is the most abundant enzyme on Earth — examiners love this fact.
C₆H₁₂O₆ + 6O₂ → 6CO₂ + 6H₂O + ATP (energy released)
1
Glycolysis
Cytoplasm

Glucose (6C) is phosphorylated using 2 ATP, then split into two molecules of triose phosphate (3C). Each triose phosphate is then oxidised to pyruvate (3C), producing 4 ATP (net gain: 2 ATP) and 2 NADH.

Glycolysis is anaerobic — it doesn't require oxygen. If oxygen is absent, pyruvate enters anaerobic pathways (fermentation) instead of the link reaction.

InputsGlucose, 2 ATP, 2 NAD⁺
Outputs2 Pyruvate, 4 ATP (net 2), 2 NADH
Exam tip: The net gain is 2 ATP, not 4 — you must subtract the 2 ATP used in phosphorylation. Examiners penalise this error.
2
Link Reaction
Mitochondrial matrix

Each pyruvate (3C) is decarboxylated (loses CO₂) and combined with coenzyme A to form acetyl CoA (2C). NAD⁺ is reduced to NADH. This happens twice per glucose.

Inputs2 Pyruvate, 2 NAD⁺, 2 CoA
Outputs2 Acetyl CoA, 2 CO₂, 2 NADH
Exam tip: The link reaction produces no ATP directly. Its role is to feed acetyl groups into the Krebs cycle.
3
Krebs Cycle
Mitochondrial matrix

Acetyl CoA (2C) combines with oxaloacetate (4C) to form citrate (6C). Through a series of reactions, citrate is gradually decarboxylated and oxidised, regenerating oxaloacetate.

Per turn: 1 ATP (via GTP), 3 NADH, and 1 FADH₂ are produced. Two turns per glucose molecule.

Inputs (per turn)Acetyl CoA, 3 NAD⁺, FAD, ADP + Pi, oxaloacetate
Outputs (per turn)2 CO₂, 3 NADH, 1 FADH₂, 1 ATP, CoA (recycled)
Exam tip: Per glucose: the Krebs cycle turns TWICE. So total = 2 ATP, 6 NADH, 2 FADH₂, 4 CO₂. Know these numbers.
4
Oxidative Phosphorylation
Inner mitochondrial membrane (cristae)

NADH and FADH₂ donate electrons to the electron transport chain on the inner mitochondrial membrane. As electrons pass through protein complexes, energy is released and used to pump H⁺ ions from the matrix into the intermembrane space.

H⁺ ions flow back through ATP synthase (chemiosmosis), generating approximately 28-34 ATP. Oxygen is the final electron acceptor, combining with H⁺ and electrons to form water.

InputsNADH, FADH₂, O₂, ADP + Pi
Outputs~28-34 ATP, H₂O, NAD⁺, FAD (recycled)
Exam tip: If asked 'why is oxygen essential?' — it's the final electron acceptor. Without it, electrons back up, the ETC stops, NADH can't be reoxidised, and the Krebs cycle halts too. Domino effect.
30–38
Total ATP per glucose (theoretical maximum)

Glycolysis: 2 | Link: 0 | Krebs: 2 | Oxidative Phosphorylation: 28-34